Concepedia

Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis

Ruchika Gupta, Sompal Singh, Suresh Hedau, Sonu Nigam, Bhudev C. Das, Ishwar Singh, Ashish Kumar Mandal

Journal of Clinical Pathology · 2006 · 70 citations · 14 references

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Abstract

The spindle cell component of SpCC is intermixed with cells that are morphologically mesenchymal but express dual antigen-positivity characteristic of epithelial (cytokeratin) and mesenchymal (vimentin) cells. These, possibly, are cells in transition suggesting that SpCC may be a sarcomatous metaplasia of SCC.

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