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Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Wolfgang Kandioller, Evelyn Balsano, Samuel M. Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael A. Jakupec, Walter Berger, Bernhard K. Keppler, Christian G. Hartinger

Chemical Communications · 2013 · 139 citations · 13 references

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Abstract

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

References

13

Areneruthenium complexes as anticancer agents

Georg Süß‐Fink · Dalton Transactions · 2009 · 635 citations

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Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

Christian G. Hartinger, Nils Metzler‐Nolte, Paul J. Dyson · Organometallics · 2012 · 553 citations · Full text

, , +13

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

Andrea Kurzwernhart, Wolfgang Kandioller, Caroline Bartel et al. · Chemical Communications · 2012 · 138 citations

, , +12

Pyrone derivatives and metals: From natural products to metal-based drugs

Wolfgang Kandioller, Andrea Kurzwernhart, Muhammad Hanif et al. · Journal of Organometallic Chemistry · 2010 · 97 citations

, , +12

β-Lapachone Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells

Lili Huang, Arthur B. Pardee · Molecular Medicine · 1999 · 75 citations · Full text

, , +14