Increased Systemic and Plaque Inflammation in <i>ABCA1</i> Mutation Carriers With Attenuation by Statins

Abstract

Our data suggest a proinflammatory state in ABCA1 mutation carriers as reflected by an increased positron emission tomography-MRI signal in nonstatin using subjects, and increased circulating cytokines. The increased inflammation in ABCA1 mutation carriers seems to be attenuated by statins.