A Response Surface Analysis of Propofol–Remifentanil Pharmacodynamic Interaction in Volunteers

Abstract

The response surface models reveal the tremendous synergy between remifentanil and propofol. The surface morphologic features give some indication of the relative contribution of sedation and analgesia to blunting subject response. Further, the results of this investigation validate the volunteer study paradigm and use of surrogate effect measures for its clinical relevance.