<i>Toll‐Like Receptor 4 +</i>3725 G/C Polymorphism, <i>Helicobacter pylori</i> Seropositivity, and the Risk of Gastric Atrophy and Gastric Cancer in Japanese

Abstract

Our study found that TLR4+3725 G/C polymorphism was a risk factor of severe gastric atrophy in H. pylori seropositive Japanese. Our results underscored the significance of the variations in host innate immunity due to TLR4 polymorphism as genetic predispositions to gastric precancerous lesions in Eastern Asian populations with the same backgrounds.