A human immunodeficiency virus protease inhibitory substance from <i>Swietenia mahagoni</i>

Abstract

For the purpose of finding anti-HIV agents from natural sources, various plant extracts were screened for their inhibitory activity against HIV-protease, an enzyme essential for viral proliferation. By bioassay-directed fractionation of the methanol extract of Swietenia mahagoni (bark) which had shown inhibitory activity against this enzyme, we isolated and identified chlorogenic acid methyl ester as a inhibitory substance, its 50% inhibitory concentration being less than 40 μg/ml. © 1997 John Wiley & Sons, Ltd.