Enhancement of methoxamine‐induced contractile responses of rat ventricular muscle in streptozotocin‐induced diabetes is associated with<i>α</i>_1Aadrenoceptor upregulation

Abstract

These results suggest that impairments of beta-adrenergic and Ca(2+)-handling mechanisms occur early in the development of cardiomyopathy in STZ-induced diabetic rats, and that this is followed by augmentation of alpha(1A) adrenoceptor-mediated inotropy due to alpha(1A) adrenoceptor upregulation.