Daily morphine injection and withdrawal disrupt 24-h wheel running and PERIOD2 expression patterns in the rat limbic forebrain

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Psychopharmacology, Pharmacotherapy, Synaptic Dopamine Concentrations +18

Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology

Robert E. Watson, Stanley J. Wiegand, Richard W. Clough et al. · Peptides · 1986 · 944 citations

Inflammation, Immunocytochemical Technique, Long-term Peptide Immunoreactivity +7

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

George K. Aghajanian · Nature · 1978 · 799 citations

Behavioral Neuroscience, Neuroanatomy, Medicine +14

The mPer2 gene encodes a functional component of the mammalian circadian clock

Binhai Zheng, David W. Larkin, Urs Albrecht et al. · Nature · 1999 · 707 citations

Developmental Biology, Medicine, Genetics +9

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.

M.G. Lacey, Nicola Biagio Mercuri, R. Alan North · The Journal of Physiology · 1987 · 613 citations · Full text