Effects of Diet on the Activities of Enzymes Related to Lipogenesis in Rat Liver and Adipose Tissue

Abstract

The activities of glucoses-phosphate dehydrogenase, malic enzyme, and pyruvate kinase were significantly higher in the livers and adipose tissues from rats fed purified diets than in these tissues from rats fed commercial lab chow. The type of carbohydrate fed in the purified diet did not have a significant effect on the final levels of the three enzymes in epididymal adipose tissue, but did affect the levels of these enzymes in the liver: rats fed sucrose or invert sugar had higher activities than those fed glucose or starch. The activity of malic enzyme was higher in the livers of rats fed diets containing glucose than in those fed starch. No significant differences in enzyme activities were observed between rats fed diets containing sucrose or invert sugar.