Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice - Concepedia

Concepedia

Publication | Open Access

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

DOI Full Paper Access

327

Citations

41

References

2011

Year

Young Lee, May-Yun Wang, Xiu Quan Du, Maureen Charron, Roger H. Unger

Abstract

We conclude that blocking glucagon action prevents the deadly metabolic and clinical derangements of type 1 diabetic mice.

References

	Year	Citations
THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS RogerH Unger, Lelio Orci The Lancet Metabolic SyndromeInsulin SignalingGlycosylationPhysiologyGlycobiology	1975	593
Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice Richard W. Gelling, Xiaoqing Du, Darwin S. Dichmann, Proceedings of the National Academy of Sciences	2003	552
Prevention of Human Diabetic Ketoacidosis by Somatostatin John E. Gerich, Mara Lorenzi, Dennis M. Bier, New England Journal of Medicine ObesityMetabolic SyndromeDiabetes ManagementInsulin SignalingInsulin Lack	1975	356
THE EFFECTS OF TOTAL STARVATION UPON THE LEVELS OF CIRCULATING GLUCAGON AND INSULIN IN MAN* Roger H. Unger, Anna M. Eisentraut, Leonard L. Madison Journal of Clinical Investigation Metabolic SyndromeNutritionEnergy HomeostasisInsulin ManagementPhysiology	1963	345
Leptin therapy in insulin-deficient type I diabetes May-Yun Wang, Lijun Chen, Gregory O. Clark, Proceedings of the National Academy of Sciences ImmunologyInsulin SignalingMetabolic SyndromeTranslational MedicineHypothalamic Peptide	2010	326
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ Stephan Herzig, Susan Hedrick, Ianessa Morantte, Nature Molecular PhysiologySignal TransductionBiochemistryMetabolic FunctionsLiver Physiology	2003	307
Insulin within islets is a physiologic glucagon release inhibitor. Hiroshi Maruyama, Akitaka Hisatomi, Lelio Orci, Journal of Clinical Investigation	1984	296
MEASUREMENTS OF ENDOGENOUS GLUCAGON IN PLASMA AND THE INFLUENCE OF BLOOD GLUCOSE CONCENTRATION UPON ITS SECRETION* Roger H. Unger, Anna M. Eisentraut, Mary Sue McCall, Journal of Clinical Investigation Insulin ManagementPhysiologyBlood Glucose MonitoringMetabolismHyperglycemia	1962	278
Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene Kristina Hedbacker, Kıvanç Birsoy, Robert W. Wysocki, Cell Metabolism Metabolic SyndromeGrowth HormoneLeptin-regulated GeneDiabetesImmunology	2010	277
Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis Christian Meyer, Jean M. Dostou, Stephen Welle, American Journal of Physiology-Endocrinology and Metabolism	2002	266

Page 1