Radiology · 1971 · 10 citations · 32 references
MedicineOncologyPharmacologyCancer PharmacologyChemotherapyNeuro-oncologyBlood-brain Barrier ToxicityBrain TumorsCentral Nervous System Tumor PharmacotherapyCytotoxic ChemotherapyGlioblastomaGlioma RadiotherapyGlioblastoma ChemotherapyGlioma ChemotherapyRadiobiology Of GliomaTreatment-related Neurotoxicity
Mice bearing intracranial gliomas were treated with BCNU (1,3-bis(chloroethyl)-l-nitrosourea), Ara-C (cytosine arabinoside), and copper hematoporphyrin with and without head irradiation. The strongest effect was noted with BCNU, as would be expected from brain-barrier and cell age-specific activity of the drug.
32