Effects of diclofenac and L-745,337, a selective cyclooxy-genase-2 inhibitor, on prostaglandin E2 formation in tissue from human colonic mucosa and chronic bursitis

Abstract

Background: Although many combination therapies have been proposed, there is still interest in identifying simple, inexpensive, effective protocols with high rates of success.Aim: To investigate the role of the new Soluble bismuth RBC in twice-a-day therapy for H. pylori infection.Methods: Patients with histologically and culture proven 11. pylori infection received RBC 400 rag, tetracycline HC1 500 rag, and clarithromycin 500 rag, each b.i.d, for 14 days followed by 300 mg ranitidine for 4 additonal weeks.Outcome was assessed 4 or more weeks after the end of antimicrobial therapy by repeat endoscopy with histology and culture or in a few cases urea breath testing.Results: 53 patients have completed therapy.There were 50 men and 3 women average age = 56 years.All patients had clarithromycin-sensitive