International Journal of STD & AIDS · 2002 · 69 citations · 0 references
Veterinary MedicineImmunologyInfectious DiseasesClinical ImmunologyImmunology Of Infectious DiseasesInflammationBacterial InfectionsCentral Nervous System InfectionsHealthcare-associated InfectionsImmune-mediated Sequelae Of InfectionInfection ManagementInfectious InflammationCryptococcal Disease ManagementCryptococcal Infection TreatmentCryptococcal MeningitisFluconazole TherapyFungal MeningitisHighly Active Antiretroviral TherapyHiv Antiretroviral TherapyImmune Reconstitution Syndrome
We report a case of paradoxical recurrent meningitis in response to initiation of highly active antiretroviral therapy in a patient receiving maintenance fluconazole for a previous diagnosis of cryptococcal meningitis. We describe the unusual radiographic and histopathologic findings which are consistent with an immune reconstitution induced paradoxical inflammatory response to residual cryptococcal infection.