Spirolides B and D, two novel macrocycles isolated from the digestive glands of shellfish

Abstract

Two polar lipid-soluble macrocycles 1 and 2, containing a spiro-linked tricyclic ether ring system and an unusual seven-membered spiro-linked cyclic iminium moiety, have been isolated from the digestive glands of mussels (Mytilus edulis) and scallops (Placopecten magellanicus).