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Development of an SPE-LC–MS/MS method for simultaneous quantification of bosentan and its active metabolite hydroxybosentan in human plasma to support a bioequivalence study

Spe-lc–ms/ms MethodBiochemistryMedicineBioanalysisMass SpectrometryHuman PlasmaAnalytical ChemistryLiquid ChromatographyClinical ChemistryPharmacologyPharmacokineticsChromatographySimultaneous QuantificationDrug Analysis