Specfific coagulation factor adsorption as related to functional groups on surfaces

Abstract

Abstract Factor assays of normal citrated plasma following incubation with nonleaching heparinized surfaces in high surface area–plasma volume ratios showed a marked pattern of reduction in factor IX activity, with lesser depression of II and X. No or modest effect on other factors was observed. In particular, no significant adsorption of factor XII (Hageman) by either cationic or anionic surfaces, was found. No consistent pattern of effects was seen with a group of strongly anionic surfaces, analogous to the sulfate and sulfamate groupings of the heparin molecule. However, certain members of this class showed profound effects on factor XI.