Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

Daniel Fishman, Gary Faulds, Rachel Jeffery et al. · Journal of Clinical Investigation · 1998 · 2.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Altered rectal perception is a biological marker of patients with irritable bowel syndrome

Howard Mertz, Bruce D. Naliboff, Julie Munakata et al. · Gastroenterology · 1995 · 990 citations

Medicine, Clinical Sciences, Internal Medicine +11

Activation of the mucosal immune system in irritable bowel syndrome

V. S. Chadwick, Wangxue Chen, Dairu Shu et al. · Gastroenterology · 2002 · 831 citations · Full text

Life Sciences, Immunology, Pathobiology +14

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

Herbert Tilg, Elizabeth Trehu, MB Atkins et al. · Blood · 1994 · 794 citations · Full text

Life Sciences, Immunology, Pharmacology +14

Psychosocial Factors in the Irritable Bowel Syndrome

Douglas A. Drossman, Daphne C. McKee, Robert S. Sandler et al. · Gastroenterology · 1988 · 762 citations

Medicine, Psychiatry, Psychology +12