Epidemiology and Infection · 2009 · 55 citations · 37 references
Veterinary MedicineInfectious Disease ControlInfectious DiseasesImmunizationInfectious Disease EpidemiologyVaccinologyHerd ImmunityImmune Response To VaccinationTransmission DynamicsVaccinationVaccine EffectivenessVaccine-preventable DiseasesHerd Immunity ModelingIndirect EffectsInfectious Disease ModelsMathematical Modeling Of TransmissionRotavirus GastroenteritisVaccination Effects On TransmissionVaccination Impact ModelingVaccination Impact On Transmission
Rotavirus (RV) infections progressively confer natural immunity against subsequent infection. Similarly to natural infection, vaccination with a live attenuated vaccine potentially reduces RV transmission and induces herd protection. A mathematical transmission model was developed to project the impact of a vaccination programme on the incidence of RV infection and disease for five countries in the European Union. With vaccination coverage rates of 70%, 90% and 95% the model predicted that, in addition to the direct effect of vaccination, herd protection induced a reduction in RV-related gastroenteritis (GE) incidence of 25%, 22% and 20%, respectively, for RV-GE of any severity, and of 19%, 15%, and 13%, respectively, for moderate-to-severe RV-GE, 5 years after implementation of a vaccination programme.
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Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases
Joël Mossong, Niel Hens, Mark Jit et al. · PLoS Medicine · 2008 · 3.2K citations · Full text
Veterinary Medicine, Infectious Diseases, Population Health Sciences +15