Palladium-Catalyzed Intramolecular δ-Lactam Formation of Aryl Halides and Amide-Enolates: Syntheses of Cherylline and Latifine

Abstract

[reaction: see text] Palladium-catalyzed intramolecular carbon-carbon bond formation of aryl halides and amide-enolates gave 4-arylisoquinoline derivatives in good yields, which were further converted into the isoquinoline alkaloids cherylline and latifine.