Concepedia

A New Synthesis of γ-Substituted α-Methylene-γ-butyrolactones (2-Methylene-4-alkanolides) using Catalysis by SnCI<sub>2</sub>/Amberlyst 15

Patrice Talaga, Marcel Schaeffer, Claude Benezra, Jean‐Luc Stampf

Synthesis · 1990 · 19 citations · 0 references

Concepts

Natural SciencesChemistryCatalysisOrganic ChemistryCatalyst PreparationCatalyst SynthesisCatalytic MaterialsCatalytic MechanismsOrganic SynthesisAsymmetric CatalysisCatalytic Reaction Mechanisms

Abstract

Reaction of α-bromomethylacrylic acid with aldehydes or ketones in an SnCl2/amberlyst 15/THF/H2O system affords 2-methylene-4-alkanolides in mostly good yields.