Journal of the American Medical Association · 1924 · 38 citations · 1 references
PharmacyPharmacologyToxicologyAnalytical ToxicologyHeavy Metal ToxicologyPharmaceutical ToxicologyMercury PoisoningMercury ToxicologyMercury Poisoning TreatmentRabbit Drug ToxicityToxicity In AnimalsToxicologic Findings
In our first paper on mercurochrome-220 soluble,<sup>1</sup>experiments were cited to show that it could be introduced intravenously in doses of 5 mg. per kilogram of body weight in rabbits and 10 mg. per kilogram in dogs, with impunity. In this paper we detailed a prolonged search which we had made with many old and new combinations of mercury and of dyes to find a germicide which would not coagulate albumin and was nontoxic. We showed that mercurochrome answered these requirements and could be used in wounds in a 1 per cent, solution. Our toxicity experiments were confirmed by Piper<sup>2</sup>on both animals and human subjects. His clinical results have been most striking. Later it was shown in our laboratories, by Hill and Colston<sup>3</sup>that, after the intravenous administration of 1, 2.5, 5 and 10 mg. per kilogram of mercurochrome to normal rabbits, the urine became either
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