Antimicrobial Agents and Chemotherapy · 1992 · 39 citations · 6 references
Pharmacokinetic StudiesMixed-phase ColumnAntifungal AgentGas ChromatographyAntifungal AgentsMedicineBioanalysisCerebrospinal FluidLaboratory MedicineClinical MycologyAnalytical ChemistryLiquid ChromatographyClinical ChemistryChromatographic AnalysisPharmacologyChromatographyHigh-performance Liquid ChromatographyDrug Analysis
A mixed-phase liquid chromatographic column was used to assay fluconazole in plasma, serum, and cerebrospinal fluid. The assay was linear from 0.2 to 20 micrograms/ml, with an average coefficient of variation of less than 5%. The partitioning of the drug between serum and cerebrospinal fluid was determined for 34 patients. The method was demonstrated to be suitable for both pharmacokinetic studies and monitoring of patients receiving treatment with this antifungal agent.
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Michael Humphrey, S. Jevons, Michael H. Tarbit · Antimicrobial Agents and Chemotherapy · 1985 · 363 citations · Full text
Unchanged Drug, Pharmaceutical Science, Pharmacokinetic Evaluation +13
Carola A.S. Arndt, Thomas J. Walsh, Cynthia Lester McCully et al. · The Journal of Infectious Diseases · 1988 · 167 citations
Pediatric Branch, Diagnostic Mycology, Microbial Pathogens +22