Concepedia

IGF-II Serum Levels Are Normal in Children with Silver-Russell Syndrome Who Frequently Carry Epimutations at the<i>IGF2</i>Locus

Gerhard Binder, Ann-Kathrin Seidel, Karin Weber, Martin Haase, H Wollmann, Michael B. Ranke, Thomas Eggermann

The Journal of Clinical Endocrinology & Metabolism · 2006 · 50 citations · 14 references

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Abstract

Our data render it unlikely that demethylation of ICR1 on 11p15 does cause diminished IGF-II serum levels in children with SRS. This observation does not exclude deficient IGF-II action before birth.

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