Organocatalytic Asymmetric Direct Alkylation of α-Diazoester via C−H Bond Cleavage

Abstract

A new variant of phosphoric acid-catalyzed C-C bond forming reaction, direct alkylation of alpha-diazoester, via C-H bond cleavage is presented. The resulting products, beta-amino-alpha-diazoesters, are highly functionalized and useful synthetic precursors for various types of beta-amino acids.