An Inactivated Hepatitis A Virus Vaccine Prepared from Infected Marmoset Liver

Abstract

Human hepatitis A virus, partially purified from the liver of a rufiventer marmoset infected with CR326 strain virus, was inactivated with formalin and was shown to be highly potent in stimulating homologous antibody in marmosets when administered subcutaneously at bi-weekly intervals in eight divided doses. The vaccine was shown to prevent hepatitis A in all marmosets when challenged with live hepatitis A virus in a controlled study.