Copper-Assisted Nickel Catalyzed Ligand-Free C(sp²)–O Cross-Coupling of Vinyl Halides and Phenols

Abstract

A convenient and efficient protocol has been achieved for the cross-coupling of phenols and vinyl halides by a unique Ni/Cu catalytic system for the first time, where the reaction is catalyzed by Ni and Cu is involved in the transmetalation process. This procedure provides an easy access to a library of aryl-vinyl and aryl-styrenyl ethers.