Infection and Immunity · 2005 · 113 citations · 30 references
Life SciencesMicrobiologyMolecular BiologyGene ExpressionMicrobial PathogenesisTranscriptional RegulationBacterial Gene RegulationBacterial PathogenesisBacterial Virulence FactorsMicrobial Gene Regulatory NetworksMicrobial Virulence FactorsVirulence Gene RegulationDevice-related InfectionsGlobal Virulence RegulatorsRegulatorsRegulatory Networks In Pathogenic BacteriaTranscriptional Regulation Of Virulence GenesVirulence Factor ExpressionVirulence Factor RegulationVirulence Gene Expression
The ability of Staphylococcus aureus to adapt to different environments is due to a regulatory network comprising several loci. Here we present a detailed study of the interaction between the two global regulators sae and sigmaB of S. aureus and their influence on virulence gene expression in vitro, as well as during device-related infection. The expression of sae, asp23, hla, clfA, coa, and fnbA was determined in strain Newman and its isogenic saeS/R and sigB mutants by Northern analysis and LightCycler reverse transcription-PCR. There was no indication of direct cross talk between the two regulators. sae had a dominant effect on target gene expression during device-related infection. SigmaB seemed to be less active throughout the infection than under induced conditions in vitro.
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Malcolm J. Horsburgh, Joanne Aish, Ian White et al. · Journal of Bacteriology · 2002 · 694 citations · Full text
Staphylococcal Coagulase: Mode of Action and Antigenicity
E. S. Duthie, L. Lorenz · Microbiology · 1952 · 622 citations