The anxiolytic-like activity of GR159897, a non-peptide NK2 receptor antagonist, in rodent and primate models of anxiety

Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines

Jacqueline N. Crawley, Frederick K. Goodwin · Pharmacology Biochemistry and Behavior · 1980 · 1.4K citations

Medicine, Behavioral Sciences, Pharmacology +13

Exploration of mice in a black and white test box: Validation as a model of anxiety

B. Costall, Brian J. Jones, M.E. Kelly et al. · Pharmacology Biochemistry and Behavior · 1989 · 542 citations

Social Sciences, Behavioral Sciences, Psychology +11

8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity

Stephan Hjorth, Arvid Carlsson, Per Lindberg et al. · Journal of Neural Transmission · 1982 · 515 citations

Medicine, Medicinal Chemistry, Pharmacology +9

Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

Joel W. Hughes, P. Boden, B. Costall et al. · Proceedings of the National Academy of Sciences · 1990 · 504 citations

Medicine, Medicinal Chemistry, Pharmacology +13

A potent and selective non-peptide antagonist of the neurokinin a (NK2) receptor

Xavier Emonds‐Alt, P. Vilain, P. Goulaouic et al. · Life Sciences · 1992 · 437 citations

Medicine, Neuroscience, Pharmacology +5