Highly Efficient and Versatile Acylation of Alcohols with Bi(OTf)3 as Catalyst

Abstract

A very convenient route for the acylation of alcohols is provided by using a Bi(OTf)3 catalyst [Eq. (1)]. In this protocol hindered and functionalized alcohols are acylated at 25°C, and solvents can be employed without purification. R=primary, secondary, tertiary alkyl, aryl; R′=Me, Ph, tBu.