Absence of Functional <b><i>LIN28B</i></b> Mutations in a Large Cohort of Patients with Idiopathic Central Precocious Puberty

Abstract

In vitro studies revealed that the rare LIN28B p.H199R variant identified in a girl with CPP does not affect the Lin28B function in the regulation of let-7 expression. Although LIN28B SNPs were associated with normal pubertal timing, rare variations in this gene do not seem to be commonly involved in the molecular pathogenesis of CPP.