Conjugates of a Dinuclear Zinc(II) Complex and DNA Oligomers as Novel Sequence-Selective Artificial Ribonucleases

Abstract

Even in the presence of a large excess of Zn^II ions, sequence-selective RNA hydrolysis is achieved by DNA conjugates involving a dinuclear Zn^II complex (shown schematically). This is because the cooperation of two Zn^II ions is essential for the RNA scission.