Isolation of Notoamide E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-Derived Fungus, <i>Aspergillus</i> sp.

Sachiko Tsukamoto, Hikaru Kato, Thomas J. Greshock, Hiroshi Hirota, Tomihisa Ohta, Robert M. Williams

Journal of the American Chemical Society · 2009 · 78 citations · 18 references

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Abstract

Notoamide E was identified to be a short-lived precursor in the biosynthesis of prenylated indole alkaloids in the mussel-derived Aspergillus sp. In addition, the feeding experiment of the (13)C-labeled notoamide E afforded structurally novel metabolites.

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