The acute oral toxicity of the anticoagulant brodifacoum to dogs

Abstract

The oral toxicity of an anticoagulant, brodifacoum, was tested with dogs of mixed breed, age, and sex. In the first trial using 20 dogs, predominantly under 2 years old, an acute oral LD 50 of 1.09 kg kg −1 (95% confidence limits, 0.49–2.42 kg kg − ) was derived. In the second trial with 59 mixed age dogs an acute oral LD 50 of 3.56 mg kg −1 (2.13–6.03 mg kg −1 ) resulted. No significant differences as a result of age or sex were found.