GenePaint.org: an atlas of gene expression patterns in the mouse embryo

TLDR

High‑throughput instruments were recently developed to determine gene expression patterns on tissue sections by RNA in situ hybridization. GenePaint.org implements a searchable relational database of gene identifiers and RNA probe sequences, annotates expression patterns and intensities across ~100 embryonic tissues using a standardized anatomical catalog, and provides a virtual microscope (Zoom Image Server) for interactive zooming and panning of ~15,000 high‑resolution images. The resulting images of gene expression patterns, chiefly of E14.5 mouse embryos, are accessible to the public at http://www.genepaint.org.

Abstract

High-throughput instruments were recently developed to determine gene expression patterns on tissue sections by RNA in situ hybridization. The resulting images of gene expression patterns, chiefly of E14.5 mouse embryos, are accessible to the public at http://www.genepaint.org. This relational database is searchable for gene identifiers and RNA probe sequences. Moreover, patterns and intensity of expression in approximately 100 different embryonic tissues are annotated and can be searched using a standardized catalog of anatomical structures. A virtual microscope tool, the Zoom Image Server, was implemented in GenePaint.org and permits interactive zooming and panning across approximately 15,000 high-resolution images.