Journal of Liquid Chromatography · 1984 · 10 citations · 15 references
MedicinePharmacokineticsPharmacologyBiochemical PharmacologyNeuropharmacologyPsychopharmacologyDrug DispositionRodent PharmacologyCentral Nervous System PharmacokineticsHigh-performance Liquid ChromatographyPharmacokinetic ParametersPharmacokinetics Of Neuroactive DrugsPlasma Concentration-time AnalysisQuantitative Determination
Abstract A new method for quantitative determination of apomorphine in mouse brain and rat plasma is described. The drug was extracted utilizing SEP-PAK C18 cartridge, and quantified by high performance liquid chromatography with electrochemical detector. The average recovery was 92 ± 2.8% with a day-to-day coefficient of variation of 10.2%. Apomorphine concentration in mouse brain and in rat plasma, as a function of dose and time, after injection with apomorphine-HCl were determined. The results indicate that the method is adequate for pharmacokinetic studies.
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Similarities between Neurologic Effects of L-Dopa and of Apomorphine
George C. Cotzias, Paul S. Papavasiliou, Clas Fehling et al. · New England Journal of Medicine · 1970 · 272 citations
Medicine, Neuroscience, Pharmacology +17
Schizophrenic Symptoms Improve with Apomorphine
Carol A. Tamminga, Martin Schaffer, Robert C. Smith et al. · Science · 1978 · 231 citations
Medicine, Pharmacology, Psychiatry +17