Effects of β₃‐adrenoceptor stimulation on prostaglandin E₂–induced bladder hyperactivity and on the cardiovascular system in conscious rats

Abstract

The present results clearly demonstrated that the beta(3)-AR agonist prolonged the micturition interval without producing significant cardiovascular side effects. The human detrusor, like the rat detrusor, relaxes on beta(3)-AR stimulation. Provided that these results are valid in humans, selective beta(3)-AR agonists might be clinically useful for controlling a certain type of bladder overactivity.