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The Peripheral Nerve Allograft in the Primate Immunosuppressed with Cyclosporin A
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1992
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Peripheral Nerve InjuryImmunologyCyclosporin APeripheral Nerve AllograftTissue TransplantationSurgeryPeripheral NervePeripheral NervesImmunotherapyOrthopaedic SurgeryPeripheral Nervous SystemRegenerative MedicineNerve GraftsPeripheral Nerve AllograftsNerve RegenerationTransplantation SurgeryAutoimmunityNervous SystemImmunosuppressive TherapyPhysiologyElectrophysiologyWound HealingImmunosuppressionMedicineGraft Rejection
Nerve regeneration across peripheral nerve allografts and control autografts in primates immunosuppressed with Cyclosporin A was quantitatively evaluated by electrophysiologic and histologic methods. Twelve cynomolgus monkeys received 3-cm autografts and allografts in contralateral ulnar nerves. They were immunosuppressed with Cyclosporin A at 25 mg/kg per day or placebo vehicle. Morphometric analysis of nerve graft and distal nerve segments was assessed at 1 year after engraftment. Quantitative electrophysiologic studies were performed percutaneously at 6 and 12 months, and compound action potentials were measured directly across the nerve grafts at 1 year. Excellent regeneration was seen across autografts and allografts in Cyclosporin A-treated and placebo-treated recipients.