Transplantation of Monocyte CC-Chemokine Receptor 2–Deficient Bone Marrow Into ApoE3–Leiden Mice Inhibits Atherogenesis

Abstract

These results provide direct evidence that CCR2 expressed by leukocytes plays a critical role in the initiation of early atherosclerosis and that pharmacological intervention in CCR2 function represents an attractive target to inhibit atherogenesis.