Concepedia

Impaired Control of Effector T Cells by Regulatory T Cells: A Clue to Loss of Oral Tolerance and Autoimmunity in Celiac Disease?

N. Hmida, Mèlika Ben Ahmed, Amel Moussa, Majd Ben Rejeb, Yosra Saïd, Nadia Kourda, Bertrand Meresse, Maha Abdeladhim, Hechmi Louzir, Nadine Cerf–Bensussan

The American Journal of Gastroenterology · 2011 · 112 citations · 29 references

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Abstract

Our results indicate that effector T lymphocytes from active CD become resistant to suppression by Tregs. This resistance might cause loss of tolerance to gluten, but also to self-antigens.

References

29

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Craig L. Bennett, Jacinda R. Christie, Fred Ramsdell et al. · Nature Genetics · 2001 · 3.3K citations

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Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

Usriansyah Hadis, Benjamin Wahl, Olga Schulz et al. · Immunity · 2011 · 874 citations

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Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma

Christophe Cellier, Éric Delabesse, Christine Helmer et al. · The Lancet · 2000 · 750 citations

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Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease

Jean-Jacques Mention, Mèlika Ben Ahmed, Bernadette Bègue et al. · Gastroenterology · 2003 · 453 citations · Full text

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Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

Stephanie McClymont, Amy Putnam, Michael R. F. Lee et al. · The Journal of Immunology · 2011 · 416 citations · Full text