Endothelial Dysfunction in Congestive Heart Failure: ACE Inhibition Vs. Angiotensin II Antagonism

Abstract

Endothelial vasomotor function in CHF rats was normalised by long-term treatment with an ACE inhibitor or an AT(1)-antagonist. Reduced aortic eNOS expression was normalised by both treatments, whereas aortic superoxide formation was only reduced by the AT(1)-antagonist Irbesartan.