Evaluation of the optimum dose of growth hormone (GH) for restoring bone mass in adult‐onset GH deficiency: results from two 12‐month randomized studies

Abstract

A GH dose of 0.5-1.0 IU/m2/day (4-9 micro g/kg/day) stimulated bone remodelling and increased BMD over 12 months in patients with severe GHDA, irrespective of gender. A higher dose (1.7 IU/m2/day congruent with 15 micro g/kg/day) was associated with initial declines in forearm and whole-body BMD.