Concepedia

Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1β) production

Takayuki Matsuda, Taro Aoki, Tadaaki Ohgiya, Tomoyuki Koshi, Masao Ohkuchi, Hiromichi Shigyo

Bioorganic & Medicinal Chemistry Letters · 2001 · 14 citations · 12 references

DOI

Concepts

References

12

Biologic basis for interleukin-1 in disease

CA Dinarello · Blood · 1996 · 4.4K citations · Full text

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Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse

S. T. Irwin · Psychopharmacology · 1968 · 1.2K citations

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Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

Charles Hannum, Carol Wilcox, William P. Arend et al. · Nature · 1990 · 1.1K citations

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Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

K. Ohlsson, P. Björk, Magnus Bergenfeldt et al. · Nature · 1990 · 856 citations

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Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia.

E Fischer, Michael A. Marano, Kimberly J. Van Zee et al. · Journal of Clinical Investigation · 1992 · 335 citations · Full text

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