Journal of the American Society for Mass Spectrometry · 1990 · 96 citations · 3 references
Natural SciencesChemistryAnalytical ChemistryChromatographic AnalysisMass Spectrometric AnalysisAnalytical ChromatographyChromatographyGas ChromatographyInstrumental AnalysisLiquid ChromatographyMass SpectrometryAnalytical Liquid ChromatographyChromatographic InstrumentationHigh-performance Liquid ChromatographyHigh-performance Liquid Chromatography-mass SpectrometryLiquid Chromatography-mass SpectrometryLiquid Chromatography-mass Spectrometry AnalysisMass Spectrometry-compatible Mobile PhasesMobile Phase Effects
Enhancements in ion abundances in high-performance liquid chromatography (HPLC) particle beam (PB) mass spectrometry were observed during coelution or when certain substances (e.g., ammonium acetate) were added to the mobile phase during a reverse-phase gradient elution HPLC separation. These enhancements were observed with two commercial PB interfaces and a variety of compounds generally not amenable to separation by gas chromatography. The enhancements are attributed to both improved chromatographic efficiency and a PB carrier process.
3