MODULATING BLADDER NEURO-INFLAMMATION: RDP58, A NOVEL ANTI-INFLAMMATORY PEPTIDE, DECREASES INFLAMMATION AND NERVE GROWTH FACTOR PRODUCTION IN EXPERIMENTAL CYSTITIS

Abstract

Inflammatory models of cystitis result in increased levels of TNF-alpha, SP and NGF production in the bladder, paralleling the hypothesized neuro-inflammatory etiology of IC. RDP58 decreases inflammation and neurotrophic factors in vivo and it may potentially treat bladder disorders with an inflammatory component, such as IC.