Necrosis and Angioinvasion Predict Adverse Outcome in Pancreatic Neuroendocrine Tumors After Curative Surgical Resection: Results of a Single‐Center Series

Abstract

Long-term survival of patients with P-NETs is influenced by various pathologic factors. Among our patients, there was not a significant difference in overall survival based on the diameter of the primary tumor or the lymph node status after R0 surgical resection. The presence of necrosis in the TNM and World Health Organization classification for pancreatic endocrine tumor was associated with significant poor overall survival in each classification category. Hence, necrosis represents an independent variable for poor prognosis.