Clinical Otolaryngology · 1997 · 17 citations · 0 references
PharmacyPharmacologyPharmacotherapyAllergyDrug ClearanceRhinologyAllergic RhinitisAllergic Rhinitis ManagementAllergic Rhinitis PharmacotherapyMucociliary ClearanceNasal Drug DeliveryNasal PhysiologyBeta-adrenergic AgentsCiliary Beat FrequencyDouble-blind TrialsMucociliary Clearance EffectsNasal Mucociliary ClearanceSeasonal Allergic Rhinitis TreatmentSprayTopical Nasal Therapy
In vitro studies have suggested that beta 2-adrenergic agents increase the ciliary beat frequency in human respiratory epithelium. We carried out a randomized, double-blind placebo-controlled trial to investigate the effects of a topical spray, salmeterol, on nasal mucociliary clearance using the saccharin test. Thirty-three healthy adults were recruited. There was a 21% reduction of nasal mucociliary transport time of saccharin with salmeterol compared to placebo (P = 0.0001). There was no effect of age, sex, order of treatment, interval between spray and saccharin test, or history of seasonal allergic rhinitis on the improvement in clearance times.