Tetramethyl Thiourea/Co₂(CO)₈-Catalyzed Pauson−Khand Reaction under Balloon Pressure of CO

Abstract

A Pauson-Khand type of conversion of enynes to bicyclic cyclopentenones employing the commercially available Co2(CO)8 and tetramethylthiourea (TMTU) as catalysts is described. This method allows a variety of enynes with diverse functional groups to be cyclized into cyclopentenones of interest. [reaction: see text]