Behavior Modification · 2001 · 23 citations · 16 references
MedicinePharmacotherapyPsychiatryBehavioral DisordersBehavioral MedicinePsychopharmacologyAntidepressant PharmacotherapyAntidepressant TherapyBehavior TherapyNeurodevelopmental DisordersPediatric PsychopharmacologyTreatment Of Mental DisordersAggressive Behavior ManagementAntidepressant MedicationsLong-term Efficacy EvaluationMedication AdministrationSelective Serotonin Reuptake Inhibitor TreatmentSelective Serotonin Reuptake Inhibitor UseSelf-harm BehaviorsTricyclic Antidepressant Therapy
Recent advances in pharmacological treatment of severe behavior disorders in persons with developmental disabilities suggest the use of antidepressant medication for therapeutic management. This research evaluated two antidepressant medications for treatment-resistant aggression and self-injury exhibited by two persons with developmental disabilities. Behavioral assessment data documented that sertraline (a serotonin selective reuptake inhibitor) was effective in reducing self-injurious behaviors in a 20-year-old man with severe mental retardation and clomipramine (a tricyclic antidepressant) was associated with the elimination of aggressive behavior in a 14-year-old boy with autism. Clinical effects from the medications were measured in relation to and shown to be a function of dosage level. Extended follow-up assessments revealed maintenance of treatment gains with continued medication administration.
16
Psychopharmacology: The Third Generation of Progress.
Annals of Internal Medicine · 1988 · 2K citations
Samuel M. Turner · Contemporary Psychology · 1982 · 383 citations