Auto‐Tandem Catalysis: Synthesis of Acridines by Pd‐Catalyzed C=C Bond Formation and C(<i>sp²</i>)–N Cross‐Coupling

Abstract

Abstract A facile palladium‐catalyzed synthesis of acridines has been realized by consecutive C=C double bond formation and C–N cross‐coupling. A variety of functionalized acridines can be accessed from easily available o ‐dihalobenzenes and N ‐tosylhydrazones in a single operation. This one‐pot protocol has a wide scope with respect to both coupling partners, and provides an efficient route to functionalized acridine derivatives, which are generally difficult to synthesize by previously known methods.