The Biological Half‐Life of Bromide Ions in Human Blood

Abstract

Abstract The biological half‐life of bromide ions in human blood was studied in 10 human subjects. The subjects were healthy students about 20 years old. The radioactive isotope, Br 82 , was given orally in form of NH 4 Br in water solution. Venous blood samples were drawn from the subjects twice a day. The biological half‐life of bromide ions in the blood was found to be about 12 days. The bromide ratio red blood cells/serum was found to be about 0.45. This was calculated by using the mean from ten hematocrit values obtained from every person. No bromide was found to be incorporated in fat, extracted from plasma and hemolysed blood cells by ether. Neither was there found any bromide incorporated in blood proteins. This was determined by precipitation with trichloroacetic acid, tannic acid, and phosphotungstic acid and anion exchanger, and paper electrophoresis.